Bus Tickets from San Diego (CA), US to San Luis Obispo

Find affordable bus tickets from San Diego (CA), US to San Luis Obispo with flexible options. Book your trip now

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TodayJun 4
from $89
TomorrowJun 5
from $48
FriJun 6
from $48
SatJun 7
from $63
SunJun 8
from $52
MonJun 9
from $89
TueJun 10
from $89
WedJun 11
from $89

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: June 5 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: June 5 at
    Destination city: San Luis Obispo
    Destination location: San Luis Obispo
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: June 6 at
    Destination city: San Luis Obispo
    Destination location: AMTRAK Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: June 6 at
    Destination city: San Luis Obispo
    Destination location: Cal Poly Vista Grande Dining Complex
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

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Compare 2 ways to go from San Diego to San Luis Obispo.

Average Price$34 - $155Average Duration8h 35m
11kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Average Price$65 - $89Average Duration8h 38m
39kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the train from San Diego to San Luis Obispo

Among the sustainable travel choices, the train stands out as the good way to reach San Luis Obispo. The journey takes about 8 hours 38 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.

3train per day
8h 38mAverage Duration
$65Cheapest ticket
39kgCO₂ emissions

Bus San Diego to San Luis Obispo: Trip Overview

Average ticket price$82
Average bus trip duration8h 35m
Number of daily buses2
Earliest bus departure5:15am
Distance263 miles (424 km)
Latest bus departure9:25pm

San Diego to San Luis Obispo Bus

Busbud helps you find a bus from San Diego to San Luis Obispo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from San Diego to San Luis Obispo will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from San Diego to San Luis Obispo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego (CA), US - San Luis Obispo

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/02
$84
06/03
$84
Today
$84
06/05
$84
06/06
$40
06/07
$55
06/08
$44
06/09
$84
busbud logoThe cheapest trip from San Diego to San Luis Obispo was searched and found on Jun 6, 2025 with a price of $40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to San Luis Obispo, as early as possible.

You can expect to pay from $40 to $84 for a bus ticket from San Diego to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at $40 which is on 2025-06-06.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and San Luis Obispo!

Much more than a mere vehicle taking you from San Diego to San Luis Obispo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to San Luis Obispo that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to San Luis Obispo.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to San Diego by bus?

Bus from San Diego to San Luis Obispo

You can also go to San Luis Obispo by train

Train from San Diego to San Luis Obispo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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