Next departures to San Diego
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: June 22 atDeparture city: San Luis ObispoDeparture location: Cal Poly Vista Grande Dining ComplexArrival time: June 23 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: Amtrak
Vehicle: BusDuration: - This trip is recommended because it is the: FastestDeparture time: June 22 atDeparture city: San Luis ObispoDeparture location: AMTRAK StationArrival time: June 22 atDestination city: San DiegoDestination location: Old Town San DiegoOperated by: AmtrakVehicle: BusDuration:
- Departure time: June 22 atDeparture city: San Luis ObispoDeparture location: Cal Poly Vista Grande Dining ComplexArrival time: June 23 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: AmtrakVehicle: BusDuration:
- Departure time: June 22 atDeparture city: San Luis ObispoDeparture location: AMTRAK StationArrival time: June 23 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: AmtrakVehicle: BusDuration:
Last refresh of the prices: Yesterday at 8:29 PM PDT.
Prices and availability are subject to change.
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Compare 2 ways to go from San Luis Obispo to San Diego
Busbud recommends taking the train from San Luis Obispo to San DiegoAmong the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 52 minutes, and with fares starting at just US$65, it presents an excellent value for a comfortable ride.
Bus San Luis Obispo to San Diego: Trip Overview
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San Luis Obispo to San Diego Bus
With Busbud, comparing and booking tickets for a bus from San Luis Obispo to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to San Diego.
Whether it is cheap bus tickets or more luxurious buses going to San Diego from San Luis Obispo, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in San Luis Obispo and San Diego?
Frequently asked questions on the trip San Luis Obispo - San Diego, CA, US
What is the distance between San Luis Obispo and San Diego?
San Luis Obispo and San Diego are 426 km (264 miles) apart.
What are the departure and arrival locations for buses traveling from San Luis Obispo to San Diego?
Buses departing from AMTRAK Station in San Luis Obispo will take you to Mission Valley Sheraton in San Diego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Luis Obispo to San Diego was searched and found on Jun 24, 2025 with a price of US$51To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, as early as possible.
You can expect to pay from US$51 to US$99 for a bus ticket from San Luis Obispo to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$51 which is on 2025-06-24.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from San Luis Obispo to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to San Diego.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis Obispo to San Diego.
Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to San Diego while indulging in miles on end of beautiful scenic views.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Top travelled bus routes
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Popular Buses Connecting San Luis Obispo
Buses Leaving from San Luis Obispo
- Bus from San Luis Obispo to Fremont
- Bus San Luis Obispo - San Jose
- San Luis Obispo - Los Angeles
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- Bus from San Luis Obispo to Las Vegas
- Bus San Luis Obispo - Dunsmuir
- San Luis Obispo - Ventura
- Bus from San Luis Obispo to Merced