Find coaches from Wilmington, DE to Florence, SC, US

Next departures

Next departures from Wilmington to Florence on 24 August
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Wilmington Bus Station
Bus stationCheapest
FlixBus
Newark (DE)
Florence, SCFastest
Greyhound Lines, Inc. + FlixBus
Wilmington Bus Station
Florence, SCNo tags
FlixBus
Newark (DE)
Florence, SCNo tags
FlixBus + Greyhound Lines, Inc.
Newark (DE)
Bus stationNo tags

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Compare 2 ways to travel from Wilmington to Florence

Bus
Average priceUS$57 - US$242Average duration15h 55m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$91 - US$255Average duration10h 1m
66kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Wilmington to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 10 hours 1 minute and with fares starting at just US$91, it presents an excellent value for a comfortable ride.

2train per day
10h 1mAverage duration
US$91Cheapest ticket
66kgCO₂ emissions

Bus Wilmington, DE to Florence, SC, US: Trip Overview

Average ticket priceUS$82
Average bus trip duration15h 55m
Number of daily buses6
Earliest bus departure11:20
Distance448 miles
Latest bus departure21:25

Wilmington to Florence Bus

Busbud helps you find a bus from Wilmington to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Wilmington to Florence will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Wilmington to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Wilmington, DE - Florence, SC, US

  1. What's the distance between Wilmington and Florence by coach?

    The journey from Wilmington to Florence by coach covers an approximate distance of 443 miles (714 km).

  2. How can I travel from Wilmington to Florence avoiding air travel?

    To travel from Wilmington to Florence without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
21/08
US$117
22/08
US$102
Today
US$103
24/08
US$74
25/08
US$71
26/08
No data
27/08
US$79
28/08
US$74
busbud logoThe cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on 25 Aug 2025 with a price of US$71

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US as early as possible.

You can expect to pay from US$71 to US$119 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$71, which is on 2025-08-25.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Wilmington and Florence!

Much more than a mere vehicle taking you from Wilmington to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Wilmington to Florence that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Wilmington to Florence while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Wilmington, DE to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Wilmington, DE by bus?

Bus from Florence, SC, US to Wilmington, DE

You can also go to Florence, SC, US by train

Train from Wilmington, DE to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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