Find coaches from Santa Ana, US to San Francisco, US

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Previously seen journeys

One passenger / one way

  • Departure time: 7 November at
    Departure city: Santa Ana
    Departure location: UC Irvine (Crawford Hall)
    Arrival time: 8 November at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: 7 November at
    Departure city: Santa Ana
    Departure location: UC Irvine (Crawford Hall)
    Arrival time: 8 November at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 7 November at
    Departure city: Santa Ana
    Departure location: Santa Ana Bus Station
    Arrival time: 8 November at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 7 November at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: 8 November at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 7 November at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: 8 November at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Bus Santa Ana, US to San Francisco, US: Trip Overview

Average ticket priceUS$65
Average bus trip duration10h 50m
Number of daily buses9
Earliest bus departure09:15
Distance382 miles
Latest bus departure22:50

Santa Ana to San Francisco Bus

With Busbud, comparing and booking tickets for a bus from Santa Ana to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Santa Ana to San Francisco will be provided by the most trusted bus companies.

Discover how much the bus trip from Santa Ana to San Francisco will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santa Ana, US - San Francisco, US

  1. How far is San Francisco from Santa Ana by coach?

    The journey from Santa Ana to San Francisco by coach covers an approximate distance of 378 miles (609 km).

  2. Is there a way to reach San Francisco from Santa Ana without flying?

    To travel from Santa Ana to San Francisco without flying, you can take the coaches. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/08
US$82
31/08
US$70
Today
US$155
02/09
US$62
03/09
US$58
04/09
US$60
05/09
US$51
06/09
US$55
busbud logoThe cheapest trip from Santa Ana, US to San Francisco, US was searched and found on 5 Sept 2025 with a price of US$51

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Francisco, US as early as possible.

You can expect to pay from US$51 to US$190 for a bus ticket from Santa Ana, US to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$51, which is on 2025-09-05.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santa Ana to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Santa Ana to San Francisco, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santa Ana to San Francisco will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Santa Ana to San Francisco, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Santa Ana, US by bus?

Bus from San Francisco, US to Santa Ana, US

Why choose Busbud?

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