Bus Tickets from Santa Ana, US to San Francisco, US

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TodayAug 31
from US$78
TomorrowSep 1
from US$121
TueSep 2
WedSep 3
ThuSep 4
FriSep 5
SatSep 6
SunSep 7

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 1 at
    Departure city: Santa Ana
    Departure location: Santa Ana Bus Station
    Arrival time: September 2 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 1 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 2 at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 2 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 2 at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Santa Ana
    Departure location: UC Irvine (Crawford Hall)
    Arrival time: September 2 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Bus Santa Ana, US to San Francisco, US: Trip Overview

Average Ticket PriceUS$65
Average Bus Trip Duration10h 50m
Number of daily buses9
Earliest bus departure9:15am
Distance616 km
Latest bus departure10:50pm

Santa Ana to San Francisco Bus

With Busbud, comparing and booking tickets for a bus from Santa Ana to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Santa Ana to San Francisco will be provided by the most trusted bus companies.

Discover how much the bus trip from Santa Ana to San Francisco will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santa Ana, US - San Francisco, US

  1. What is the travel distance from Santa Ana to San Francisco?

    Santa Ana and San Francisco are 609 km (378 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Santa Ana to San Francisco?

    Buses departing from Santa Ana Greyhound Bus Station in Santa Ana will take you to Hyde/Beach (Fisherman's Wharf) in San Francisco.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
US$107
08-30
US$82
Today
US$70
09-01
US$114
09-02
US$62
09-03
US$58
09-04
US$60
09-05
US$51
busbud logoThe cheapest trip from Santa Ana, US to San Francisco, US was searched and found on Sep 5, 2025 with a price of US$51

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Francisco, US, as early as possible.

You can expect to pay from US$51 to US$128 for a bus ticket from Santa Ana, US to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$51 which is on 2025-09-05.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santa Ana to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Santa Ana to San Francisco, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santa Ana to San Francisco will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Santa Ana to San Francisco, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Santa Ana, US by bus?

Bus from San Francisco, US to Santa Ana, US

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