Bus Tickets from San Ysidro, CA to Santa Ana, US

TodayAug 2
from US$45
TomorrowAug 3
from US$34
MonAug 4
from US$31
TueAug 5
from US$28
WedAug 6
from US$28
ThuAug 7
from US$29
FriAug 8
from US$29
SatAug 9
from US$29

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 3 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 3 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 3 at
    Departure city: San Ysidro
    Departure location: San Ysidro Greyhound Bus Station
    Arrival time: August 3 at
    Destination city: Santa Ana
    Destination location: Santa Ana E Santa Ana Blvd
    Operated by: Los LimousinesLos Limousines
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 3 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 3 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: San Ysidro
    Departure location: San Ysidro Greyhound Bus Station
    Arrival time: August 3 at
    Destination city: Santa Ana
    Destination location: Santa Ana E Santa Ana Blvd
    Operated by: Los LimousinesLos Limousines
    Vehicle: BusDuration:

Last refresh of the prices: Today at 5:13 AM PDT.

Prices and availability are subject to change.

Accepted payments

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Bus San Ysidro, CA to Santa Ana, US: Trip Overview

Average Ticket PriceUS$43
Average Bus Trip Duration3h
Number of daily buses22
Earliest bus departure1:15am
Distance161 km
Latest bus departure10:00pm

San Ysidro to Santa Ana Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Ysidro to Santa Ana.

Bus service from San Ysidro to Santa Ana will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from San Ysidro, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Ysidro, CA - Santa Ana, US

  1. What is the distance between San Ysidro and Santa Ana?

    San Ysidro and Santa Ana are 154 km (96 miles) apart.

  2. What are the departure and arrival locations for buses traveling from San Ysidro to Santa Ana?

    Buses departing from San Ysidro Greyhound Bus Station in San Ysidro will take you to Santa Ana Greyhound Bus Station in Santa Ana.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-31
US$24
08-01
US$26
Today
US$26
08-03
US$26
08-04
US$23
08-05
US$20
08-06
US$20
08-07
US$21
busbud logoThe cheapest trip from San Ysidro, CA to Santa Ana, US was searched and found on Aug 5, 2025 with a price of US$20

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Santa Ana, US, as early as possible.

You can expect to pay from US$20 to US$41 for a bus ticket from San Ysidro, CA to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$20 which is on 2025-08-05.

Usually LLIO will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Ysidro to Santa Ana but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from San Ysidro to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Ysidro to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from San Ysidro to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to San Ysidro, CA by bus?

Bus from San Ysidro, CA to Santa Ana, US

Why choose Busbud?

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