Bus Tickets from San Diego, CA, US to Santa Ana, US

Next departures

Next departures for San Diego to Santa Ana on September 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
San Diego (Old Town-FlixBus)
Anaheim Regional Transportation Intermodal CenterCheapest
FlixBus
UCSD Health La Jolla Station
UC Irvine (Crawford Hall)Fastest
FlixBus
San Diego (Old Town-FlixBus)
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc.
Greyhound Bus Stop
Anaheim Regional Transportation Intermodal CenterNo tags
Los Limousines
Cross Border Xpress CBX (USA)
Santa Ana E Santa Ana BlvdNo tags

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Bus San Diego, CA, US to Santa Ana, US: Trip Overview

Average Ticket PriceUS$26
Average Bus Trip Duration2h
Number of daily buses28
Earliest bus departure12:30am
Distance133 km
Latest bus departure10:30pm

San Diego to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from San Diego to Santa Ana from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to Santa Ana, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - Santa Ana, US

  1. What is the travel distance from San Diego to Santa Ana?

    The distance between San Diego and Santa Ana is approximately 133 km (83 miles).

  2. What are the departure and arrival locations for buses traveling from San Diego to Santa Ana?

    Buses departing from Mission Valley Sheraton in San Diego will take you to Santa Ana Greyhound Bus Station in Santa Ana.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-30
US$16
08-31
US$19
Today
US$19
09-02
US$17
09-03
US$16
09-04
US$16
09-05
US$15
09-06
US$17
busbud logoThe cheapest trip from San Diego, CA, US to Santa Ana, US was searched and found on Sep 5, 2025 with a price of US$15

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Ana, US, as early as possible.

You can expect to pay from US$15 to US$42 for a bus ticket from San Diego, CA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$15 which is on 2025-09-05.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Diego to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Santa Ana, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Santa Ana that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to San Diego, CA, US by bus?

Bus from Santa Ana, US to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

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