Bus Tickets from Santa Ana, US to San Diego, CA, US

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ThuSep 4
from US$23
FriSep 5
from US$25
SatSep 6
from US$25
SunSep 7
from US$25
MonSep 8
from US$24
TueSep 9
WedSep 10
ThuSep 11

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: September 5 at
    Departure city: Santa Ana
    Departure location: UC Irvine (Crawford Hall)
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Santa Ana
    Departure location: Santa Ana E Santa Ana Blvd
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: Cross Border Xpress CBX (USA)
    Operated by: Los LimousinesLos Limousines
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Santa Ana
    Departure location: Anaheim Regional Transportation Intermodal Center
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Bus Santa Ana, US to San Diego, CA, US: Trip Overview

Average Ticket PriceUS$26
Average Bus Trip Duration2h
Number of daily buses32
Earliest bus departure5:55am
Distance133 km
Latest bus departure10:15pm

Santa Ana to San Diego Bus

Busbud helps you find a bus from Santa Ana to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Santa Ana to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from Santa Ana, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Santa Ana, US - San Diego, CA, US

  1. What is the distance between Santa Ana and San Diego?

    The distance between Santa Ana and San Diego is approximately 133 km (83 miles).

  2. What are the departure and arrival locations for buses traveling from Santa Ana to San Diego?

    Buses departing from Santa Ana Greyhound Bus Station in Santa Ana will take you to Mission Valley Sheraton in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$19
09-01
US$19
Today
US$19
09-03
US$18
09-04
US$16
09-05
US$17
09-06
US$17
09-07
US$18
busbud logoThe cheapest trip from Santa Ana, US to San Diego, CA, US was searched and found on Sep 4, 2025 with a price of US$16

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Diego, CA, US, as early as possible.

You can expect to pay from US$16 to US$57 for a bus ticket from Santa Ana, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$16 which is on 2025-09-04.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Santa Ana and San Diego!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Ana to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Ana to San Diego.

Make a music playlist for your bus ride from Santa Ana to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Santa Ana, US by bus?

Bus from San Diego, CA, US to Santa Ana, US

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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