Find coaches from Panama City, US to Tupelo

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Bus Panama City to Tupelo: Trip Overview

Average ticket priceUS$141
Average bus trip duration16h 35m
Number of daily buses1
Earliest bus departure12:50
Distance327 miles

Panama City to Tupelo Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Panama City to Tupelo.

Bus service from Panama City to Tupelo will be provided by the most trusted bus companies.

Discover how much the bus trip from Panama City to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Panama City, US - Tupelo

  1. What's the distance between Panama City and Tupelo by coach?

    The journey from Panama City to Tupelo by coach covers an approximate distance of 332 miles (535 km).

  2. How can I travel from Panama City to Tupelo avoiding air travel?

    To travel from Panama City to Tupelo without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
18/06
US$171
19/06
No data
Today
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21/06
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22/06
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busbud logoThe cheapest trip from Panama City to Tupelo was searched and found on 18 Jun 2025 with a price of US$171

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Tupelo as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Panama City to Tupelo but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Panama City to Tupelo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Panama City to Tupelo will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Tupelo while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Panama City by bus?

Bus from Panama City to Tupelo

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