Find coaches from Tupelo to Indianapolis

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Next departures

Next departures from Tupelo to Indianapolis on 17 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Tupelo (Brothers Quick Stop)
Indianapolis Bus StationCheapest
Greyhound Lines, Inc.
Tupelo (Brothers Quick Stop)
Indianapolis Bus StationFastest
Greyhound Lines, Inc.
Tupelo (Brothers Quick Stop)
Indianapolis Bus StationNo tags
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Transit CenterNo tags
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Transit CenterNo tags

Accepted payments

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  • American Express
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Bus Tupelo to Indianapolis: Trip Overview

Average ticket priceUS$83
Average bus trip duration20h 30m
Number of daily buses5
Earliest bus departure05:35
Distance407 miles
Latest bus departure23:15

Tupelo to Indianapolis Bus

Busbud helps you find a bus from Tupelo to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tupelo to Indianapolis.

Whether it is cheap bus tickets or more luxurious buses going to Indianapolis from Tupelo, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Tupelo - Indianapolis

  1. How far is Indianapolis from Tupelo by coach?

    The journey from Tupelo to Indianapolis by coach covers an approximate distance of 406 miles (655 km).

  2. What is the best way to go from Tupelo to Indianapolis without flying?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
14/09
No data
15/09
No data
Today
US$75
17/09
US$66
18/09
US$71
19/09
No data
20/09
US$69
21/09
No data
busbud logoThe cheapest trip from Tupelo to Indianapolis was searched and found on 17 Sept 2025 with a price of US$66

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis as early as possible.

You can expect to pay from US$66 to US$112 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$66, which is on 2025-09-17.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tupelo and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tupelo to Indianapolis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tupelo to Indianapolis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Tupelo by bus?

Bus from Indianapolis to Tupelo

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