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One passenger / one way
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Compare 2 ways to go from Greenville to Jacksonville
Busbud recommends taking the bus from Greenville to JacksonvilleAmong the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 15 hours 35 minutes, and with fares starting at just US$65, it presents an excellent value for a comfortable ride.
Bus Greenville, SC to Jacksonville, FL: Trip Overview
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Greenville to Jacksonville Bus
Busbud helps you find a bus from Greenville to Jacksonville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Jacksonville.
Discover how much the bus trip from Greenville to Jacksonville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Greenville and Jacksonville?
Frequently asked questions on the trip Greenville, SC - Jacksonville, FL
What is the travel distance from Greenville to Jacksonville?
The distance covered from Greenville to Jacksonville is 508 km (315 miles).
What are the departure and arrival locations for buses traveling from Greenville to Jacksonville?
Buses traveling this route start their trip at Guadalajara Supermarket Bus Stop, in Greenville, and end it at Jacksonville Amtrak Station, in Jacksonville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Jacksonville, FL was searched and found on Sep 4, 2025 with a price of US$70To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Jacksonville, FL, as early as possible.
You can expect to pay from US$70 to US$70 for a bus ticket from Greenville, SC to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$70 which is on 2025-09-04.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Jacksonville!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Jacksonville.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Jacksonville will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Jacksonville.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
What's the cheapest way to go from Greenville, SC to Jacksonville, FL?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular Buses Connecting Greenville
Buses Leaving from Greenville
- Bus from Greenville to Spartanburg
- Bus Greenville - Charleston
- Greenville - Charleston
- Bus from Greenville to Greensboro
- Bus Greenville - Chicago
- Greenville - Miami
- Bus from Greenville to Atlanta
- Bus Greenville - New York City
- Greenville - Lima
- Bus from Greenville to Houston
- Bus Greenville - New Orleans
- Greenville - Columbus
- Bus from Greenville to Rocky Mount
- Bus Greenville - Grand Rapids
- Greenville - Orlando
Buses Going to Greenville
- Bus from Atlanta to Greenville
- Bus Burlington - Greenville
- Nashville - Greenville
- Bus from Knoxville to Greenville
- Bus Savannah - Greenville
- Orlando - Greenville
- Bus from Charlotte to Greenville
- Bus Memphis - Greenville
- New Haven - Greenville
- Bus from Winston-Salem to Greenville
- Bus Southern Pines - Greenville
- Florence - Greenville
- Bus from Lumberton to Greenville
- Bus Newark - Greenville
- Lima - Greenville
Popular Buses Connecting Jacksonville
Buses Leaving from Jacksonville
- Bus from Jacksonville to Jacksonville
- Bus Jacksonville - Miami
- Jacksonville - Atlanta
- Bus from Jacksonville to Savannah
- Bus Jacksonville - Gainesville
- Jacksonville - Gainesville
- Bus from Jacksonville to Orlando
- Bus Jacksonville - Columbus
- Jacksonville - Ocala
- Bus from Jacksonville to New York City
- Bus Jacksonville - Roanoke
- Jacksonville - Lafayette
- Bus from Jacksonville to Corpus Christi
- Bus Jacksonville - Port Saint Lucie
- Jacksonville - Key West
Buses Going to Jacksonville
- Bus from Jacksonville to Jacksonville
- Bus Orlando - Jacksonville
- Tampa - Jacksonville
- Bus from Miami to Jacksonville
- Bus San Marcos - Jacksonville
- Boston - Jacksonville
- Bus from Gainesville to Jacksonville
- Bus Atlanta - Jacksonville
- Port Saint Lucie - Jacksonville
- Bus from Meridian to Jacksonville
- Bus Buffalo - Jacksonville
- Columbus - Jacksonville
- Bus from New York City to Jacksonville
- Bus Daytona Beach - Jacksonville
- Houston - Jacksonville
Popular routes in this country
- Bus from Washington to New York City
- Bus Boston - New York City
- New York City - Boston
- Bus from Buffalo to New York City
- Bus Philadelphia - New York City
- Niagara Falls - New York City
- Bus from Baltimore to New York City
- Bus Detroit - Chicago
- Albany - New York City
- Bus from Los Angeles to San Francisco
- Bus Baton Rouge - New Orleans
- Miami - Orlando
- Bus from Los Angeles to San Diego
- Bus Las Vegas - Los Angeles
- Atlanta - Savannah