Bus Tickets from Jacksonville, FL to Greenville, SC

Next departures

Next departures for Jacksonville to Greenville on September 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Jacksonville Bus Station
1116 Woodruff RdCheapest
FlixBus + Greyhound Lines, Inc.
Jacksonville Bus Station
1116 Woodruff RdFastest
FlixBus
Jacksonville Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Jacksonville Bus Station
1116 Woodruff RdNo tags

Accepted payments

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Compare 2 ways to go from Jacksonville to Greenville

Bus
Average PriceUS$56 - US$170Average Duration12h 15m
13kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$122 - US$567Average Duration1d 6h
46kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Jacksonville to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 12 hours 15 minutes, and with fares starting at just US$56, it presents an excellent value for a comfortable ride.

3bus per day
12h 15mAverage Duration
US$56Cheapest ticket
13kgCO₂ emissions

Bus Jacksonville, FL to Greenville, SC: Trip Overview

Average Ticket PriceUS$78
Average Bus Trip Duration12h 15m
Number of daily buses3
Earliest bus departure8:05am
Distance504 km
Latest bus departure9:45pm

Jacksonville to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Jacksonville to Greenville.

We make sure you can find a bus service from Jacksonville to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Jacksonville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Jacksonville, FL - Greenville, SC

  1. What is the distance between Jacksonville and Greenville?

    The distance between Jacksonville and Greenville is around 508 km (315 miles).

  2. What are the departure and arrival locations for buses traveling from Jacksonville to Greenville?

    Buses traveling this route start their trip at Jacksonville Amtrak Station, in Jacksonville, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
US$109
08-30
US$81
Today
US$118
09-01
US$121
09-02
US$80
09-03
No data
09-04
No data
09-05
US$58
busbud logoThe cheapest trip from Jacksonville, FL to Greenville, SC was searched and found on Sep 5, 2025 with a price of US$58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Greenville, SC, as early as possible.

You can expect to pay from US$58 to US$121 for a bus ticket from Jacksonville, FL to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$58 which is on 2025-09-05.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Jacksonville to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Jacksonville to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jacksonville to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Jacksonville to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Jacksonville, FL to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Jacksonville, FL by bus?

Bus from Greenville, SC to Jacksonville, FL

You can also go to Greenville, SC by train

Train from Jacksonville, FL to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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