Bus Tickets from San Diego, CA, US to Knoxville, TN

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Bus San Diego, CA, US to Knoxville, TN: Trip Overview

Average ticket price$600
Average bus trip duration2d 7h
Number of daily buses8
Earliest bus departure7:15am
Distance1900 miles (3063 km)
Latest bus departure7:35pm

San Diego to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from San Diego to Knoxville will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Diego, CA, US - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/28
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07/29
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Today
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07/31
$156
08/01
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08/02
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busbud logoThe cheapest trip from San Diego, CA, US to Knoxville, TN was searched and found on Jul 31, 2025 with a price of $156

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Knoxville, TN, as early as possible.

You can expect to pay from $156 to $168 for a bus ticket from San Diego, CA, US to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $156 which is on 2025-07-31.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Knoxville will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to Knoxville while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to San Diego, CA, US by bus?

Bus from San Diego, CA, US to Knoxville, TN

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