Bus Tickets from San Diego, CA, US to Indianapolis

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Previously seen trips

One passenger / one way

  • Departure time: January 11 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: January 14 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: January 11 at
    Departure city: San Diego
    Departure location: UCSD Health La Jolla Station
    Arrival time: January 14 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: January 11 at
    Departure city: San Diego
    Departure location: UCSD Health La Jolla Station
    Arrival time: January 14 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: January 11 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: January 14 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: January 11 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: January 14 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Compare 2 ways to go from San Diego to Indianapolis.

Bus
Average Price$169 - $387Average Duration2d 8h
72kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$208 - $542Average Duration2d 9h
261kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from San Diego to Indianapolis

Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 2 days, 8 hours 20 minutes and with fares starting at just $169, it presents an excellent value for a comfortable ride.

19bus per day
2d 8hAverage Duration
$169Cheapest ticket
72kgCO₂ emissions

Bus San Diego, CA, US to Indianapolis: Trip Overview

Average ticket price$235
Average bus trip duration2d 8h
Number of daily buses19
Earliest bus departure7:15am
Distance1782 miles (2874 km)
Latest bus departure7:35pm

San Diego to Indianapolis Bus

Busbud helps you find a bus from San Diego to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Diego to Indianapolis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from San Diego to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego, CA, US - Indianapolis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/01
No data
09/02
$223
Today
$201
09/04
No data
09/05
No data
09/06
No data
09/07
No data
09/08
No data
busbud logoThe cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Sep 3, 2025 with a price of $201

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Indianapolis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from San Diego, CA, US to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from Indianapolis to San Diego, CA, US

You can also go to Indianapolis by train

Train from San Diego, CA, US to Indianapolis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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