Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | 199 Spring Garden St. | Bus station | Cheapest | |||||
 | Philadelphia, 199 Spring Garden St | Florence, SC | Fastest | |||||
Greyhound Lines, Inc. + FlixBus | 199 Spring Garden St. | Florence, SC | No tags | |||||
| Philadelphia, 199 Spring Garden St | Florence, SC | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Philadelphia, 199 Spring Garden St | Bus station | No tags |
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Compare 2 ways to go from Philadelphia to Florence.
Busbud recommends taking the train from Philadelphia to FlorenceAmong the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 10 hours 22 minutes and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Bus Philadelphia, PA to Florence, SC, US: Trip Overview
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Philadelphia to Florence Bus
Busbud helps you find a bus from Philadelphia to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Philadelphia to Florence.
Discover how much the bus trip from Philadelphia to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Philadelphia and Florence?
Frequently asked questions for your trip Philadelphia, PA - Florence, SC, US
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Florence, SC, US was searched and found on Aug 25, 2025 with a price of $68To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Florence, SC, US, as early as possible.
You can expect to pay from $68 to $158 for a bus ticket from Philadelphia, PA to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2025-08-25.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Philadelphia and Florence!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Philadelphia to Florence.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Philadelphia to Florence will emit less CO2 than a car or an airplane.
Tune out to the fine sounds of your best music playlist on your bus trip from Philadelphia to Florence while indulging in miles on end of beautiful scenic views.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
What's the cheapest way to go from Philadelphia, PA to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Philadelphia
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Popular Buses Connecting Florence
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Buses Going to Florence
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