Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | Fastest | ||||
 | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Syracuse (Regional Transportation Center) | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Today at 04:31 EST.
Compare 2 ways to travel from Syracuse to Chicago
Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes and with fares starting at just £45, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Chicago?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
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Frequently asked questions about travelling by bus from Syracuse, US to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Syracuse to Chicago?
The cheapest coach tickets from Syracuse to Chicago start from £55. The average price for this route is around £69. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Syracuse to Chicago?
The average bus journey time from Syracuse to Chicago is 1d 5h, covering a distance of 591 miles. The fastest bus can take you there in 16h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Chicago route?
Several major bus companies operate on this route with 10 buses available per day, including services from Greyhound, FlixBus, New York Trailways, Adirondack Trailways.
What is the earliest and latest departure time for the bus from Syracuse to Chicago?
The earliest bus departs from Syracuse to Chicago at 03:20. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Syracuse to Chicago?
A bus journey from Syracuse to Chicago produces an estimated 24 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Syracuse to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Adirondack Trailways, with an average rating of 4.1 out of 5 stars based on 1148 reviews.
Which company has the best Wi-Fi from Syracuse to Chicago?
Based on Busbud reviews, the bus company New York Trailways has the best Wi-Fi rating with a score of 3.1.
Which bus company offers the most punctual service from Syracuse to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is Adirondack Trailways, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Adirondack Trailways, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Chicago was searched and found on 27 Feb 2026 with a price of £86To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.
You can expect to pay from £86 to £214 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £86, which is on 2026-02-27.
