Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | San Diego (Old Town-FlixBus) | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | UCSD Health La Jolla Station | Fastest | ||||
 | Bus | Mesa Bus Stop | Greyhound Bus Stop | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown SD (Seaport) | No tags |
Last refresh of the prices: Yesterday at 03:54 MST.
Get from Mesa to San Diego
The journey takes about 15 hours 35 minutes, and with fares starting at just £51, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Diego?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Based on 87490 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £51
Frequently asked questions about travelling by bus from Mesa to San Diego, CA, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Mesa to San Diego?
The cheapest coach tickets from Mesa to San Diego start from £51. The average price for this route is around £90. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Mesa to San Diego?
The average bus journey time from Mesa to San Diego is 15h 35m, covering a distance of 312 miles. The fastest bus can take you there in 15h 35m and is operated by Greyhound.
Which bus companies service the Mesa to San Diego route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Mesa to San Diego?
The earliest bus departs from Mesa to San Diego at 20:10. And the latest bus departs at 21:10.
What are the CO₂ emissions for the bus trip from Mesa to San Diego?
A bus journey from Mesa to San Diego produces an estimated 13 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Diego, CA, US was searched and found on 6 Jan 2026 with a price of £45To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Diego, CA, US as early as possible.
You can expect to pay from £45 to £77 for a bus ticket from Mesa to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £49, which is on 2026-01-12.
