Find coaches from Indianapolis to Charleston, SC, US

Find affordable coach tickets from Indianapolis to Charleston, SC, US with flexible options. Book your journey now

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Previously seen journeys

One passenger / one way

  • Departure time: 30 August at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: 31 August at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 16 March at
    Departure city: Indianapolis
    Departure location: Indianapolis Northeast
    Arrival time: 18 March at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: 3 May at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: 5 May at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 29 June at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: 30 June at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: 29 June at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: 30 June at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Indianapolis to Charleston

Bus
Average priceUS$107 - US$200Average duration22h
24kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$234 - US$282Average duration1d 4h
86kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Charleston

Among the sustainable travel choices, the bus stands out as a good way to reach Charleston. The journey takes about 22 hours and with fares starting at just US$107, it presents an excellent value for a comfortable ride.

1bus per day
22hAverage duration
US$107Cheapest ticket
24kgCO₂ emissions

Bus Indianapolis to Charleston, SC, US: Trip Overview

Average ticket priceUS$116
Average bus trip duration22h
Number of daily buses1
Earliest bus departure15:50
Distance585 miles
Latest bus departure23:30

Indianapolis to Charleston Bus

Busbud helps you find a bus from Indianapolis to Charleston. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Indianapolis to Charleston will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Indianapolis to Charleston, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Indianapolis - Charleston, SC, US

  1. How far is Charleston from Indianapolis by coach?

    The distance between Indianapolis and Charleston by coach is approximately 594 miles (957 km).

  2. What is the best way to go from Indianapolis to Charleston without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/08
No data
01/09
US$193
Today
No data
03/09
No data
04/09
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05/09
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06/09
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07/09
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busbud logoThe cheapest trip from Indianapolis to Charleston, SC, US was searched and found on 1 Sept 2025 with a price of US$193

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Charleston, SC, US as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Indianapolis and Charleston!

Much more than a mere vehicle taking you from Indianapolis to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Indianapolis to Charleston that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Indianapolis to Charleston, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from Indianapolis to Charleston, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Charleston, SC, US to Indianapolis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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