Find coaches from Gainesville, FL to Knoxville, TN

Find affordable coach tickets from Gainesville, FL to Knoxville, TN with flexible options. Book your journey now

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Today1 Aug
from US$127
Tomorrow2 Aug
from US$104
Sun3 Aug
Mon4 Aug
from US$127
Tue5 Aug
Wed6 Aug
Thu7 Aug
Fri8 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 2 August at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: 3 August at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 2 August at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: 2 August at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 2 August at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: 2 August at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 2 August at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: 2 August at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Gainesville, FL to Knoxville, TN: Trip Overview

Average ticket priceUS$118
Average bus trip duration21h 30m
Number of daily buses2
Earliest bus departure01:10
Distance448 miles
Latest bus departure22:40

Gainesville to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Knoxville.

Discover how much the bus trip from Gainesville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Gainesville, FL - Knoxville, TN

  1. What's the distance between Gainesville and Knoxville by coach?

    The journey from Gainesville to Knoxville by coach covers an approximate distance of 446 miles (718 km).

  2. How can I travel from Gainesville to Knoxville avoiding air travel?

    To travel from Gainesville to Knoxville without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/07
No data
31/07
No data
Today
US$182
02/08
US$102
03/08
No data
04/08
US$123
05/08
US$110
06/08
US$127
busbud logoThe cheapest trip from Gainesville, FL to Knoxville, TN was searched and found on 2 Aug 2025 with a price of US$102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Knoxville, TN as early as possible.

You can expect to pay from US$102 to US$182 for a bus ticket from Gainesville, FL to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$102, which is on 2025-08-02.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Gainesville to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Gainesville to Knoxville.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Gainesville to Knoxville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Gainesville to Knoxville.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Gainesville, FL by bus?

Bus from Gainesville, FL to Knoxville, TN

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