Find coaches from Florianópolis to Santiago, BR

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Previously seen journeys

One passenger / one way

  • Departure time: 8 September at
    Departure city: Florianópolis
    Departure location: Rodoviária de Florianópolis
    Arrival time: 9 September at
    Destination city: Santiago
    Destination location: Santiago Onibus
    Operated by: União Santa CruzUnião Santa Cruz
    Vehicle: BusDuration:
  • Departure time: 18 September at
    Departure city: Florianópolis
    Departure location: Rodoviária de Florianópolis
    Arrival time: 19 September at
    Destination city: Santiago
    Destination location: Estação Rodoviária De Santiago
    Operated by: União Santa CruzUnião Santa Cruz
    Vehicle: BusDuration:
  • Departure time: 25 September at
    Departure city: Florianópolis
    Departure location: Rodoviária de Florianópolis
    Arrival time: 26 September at
    Destination city: Santiago
    Destination location: Santiago Onibus
    Operated by: União Santa CruzUnião Santa Cruz
    Vehicle: BusDuration:
  • Departure time: 30 September at
    Departure city: Florianópolis
    Departure location: Rodoviária de Florianópolis
    Arrival time: 1 October at
    Destination city: Santiago
    Destination location: Santiago Onibus
    Operated by: União Santa CruzUnião Santa Cruz
    Vehicle: BusDuration:
  • Departure time: 12 November at
    Departure city: Florianópolis
    Departure location: Rodoviária de Florianópolis
    Arrival time: 13 November at
    Destination city: Santiago
    Destination location: Estação Rodoviária De Santiago
    Operated by: União Santa CruzUnião Santa Cruz
    Vehicle: BusDuration:

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Bus Florianópolis to Santiago, BR: Trip Overview

Average ticket priceUS$67
Average bus trip duration14h 45m
Number of daily buses1
Earliest bus departure22:00
Distance398 miles

Florianópolis to Santiago Bus

Busbud helps you find a bus from Florianópolis to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Florianópolis to Santiago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Florianópolis to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Florianópolis - Santiago, BR

  1. What's the distance between Florianópolis and Santiago by coach?

    The journey from Florianópolis to Santiago by coach covers an approximate distance of 399 miles (643 km).

  2. What is the best way to go from Florianópolis to Santiago without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/08
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29/08
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Today
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31/08
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01/09
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02/09
US$58
03/09
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04/09
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busbud logoThe cheapest trip from Florianópolis to Santiago, BR was searched and found on 2 Sept 2025 with a price of US$58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florianópolis to Santiago, BR as early as possible.

You can expect to pay from US$58 to US$73 for a bus ticket from Florianópolis to Santiago, BR based on the last 2 days. You can expect to find the cheapest price for the trip at US$58, which is on 2025-09-02.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Florianópolis and Santiago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florianópolis to Santiago, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Florianópolis to Santiago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Florianópolis to Santiago while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Florianópolis by bus?

Bus from Santiago, BR to Florianópolis

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