Cheap buses leaving Saturday
One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: 21 June atDeparture city: Des MoinesDeparture location: Des Moines (Subway)Arrival time: 21 June atDestination city: St LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
Accepted payments
Bus Des Moines to St Louis: Trip Overview
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Des Moines to St Louis Bus
Busbud helps you find a bus from Des Moines to St Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to St Louis.
Whether it is cheap bus tickets or more luxurious buses going to St Louis from Des Moines, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Des Moines and St Louis?
Frequently asked questions on the trip Des Moines - St Louis
How much does it cost to go to St Louis by bus?
The price for a coach ticket from Des Moines to St Louis starts at US$1, though the average is US$2. The actual price may differ based on factors like the time you plan to travel, the day of the week, and the coach service provider you select. To get accurate and up-to-date pricing information, check out all your options on our search tool.
How long is a coach from Des Moines to St Louis?
The average duration for a trip from Des Moines to St Louis by coach is around 18h 5m. The fastest coach journey typically takes 8h 20m. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.
At what time is the first coach from Des Moines to St Louis?
The first departure to St Louis is at 05:30. Keep in mind that departure times might change on weekends and holidays.
What's the distance between Des Moines and St Louis by coach?
The distance between Des Moines and St Louis by coach is approximately 273 miles (441 km).
What is the best way to go from Des Moines to St Louis without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Can I catch a night coach from Des Moines to St Louis?
Yes, you can find coaches leaving until 23:15 and arriving the next day. Make sure to bring a snack and a blanket to keep yourself feeling comfortable during the night.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to St Louis was searched and found on 21 Jun 2025 with a price of US$94To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to St Louis as early as possible.
You can expect to pay from US$94 to US$134 for a bus ticket from Des Moines to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$94, which is on 2025-06-21.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and St Louis!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to St Louis.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to St Louis.
Tune out to the fine sounds of your best music playlist on your bus trip from Des Moines to St Louis while indulging in miles on end of beautiful scenic views.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Top travelled bus routes
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