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One passenger / one way
- This trip is recommended because it is: Cheapest
- This trip is recommended because it is: FastestDeparture time: July 23 atDeparture city: St. LouisDeparture location: Saint LouisArrival time: July 23 atDestination city: Des MoinesDestination location: Des MoinesOperated by: Burlington Trailways
Vehicle: BusDuration: - Departure time: July 23 atDeparture city: St. LouisDeparture location: Saint LouisArrival time: July 23 atDestination city: Des MoinesDestination location: Des MoinesOperated by: Burlington TrailwaysVehicle: BusDuration:
- Departure time: July 23 atDeparture city: St. LouisDeparture location: Saint LouisArrival time: July 23 atDestination city: Des MoinesDestination location: Des MoinesOperated by: Burlington TrailwaysVehicle: BusDuration:
- Departure time: July 23 atDeparture city: St. LouisDeparture location: Saint LouisArrival time: July 23 atDestination city: Des MoinesDestination location: Des MoinesOperated by: Burlington TrailwaysVehicle: BusDuration:
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Bus St. Louis to Des Moines: Trip Overview
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St. Louis to Des Moines Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Des Moines.
We make sure you can find a bus service from St. Louis to Des Moines from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from St. Louis to Des Moines, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in St. Louis and Des Moines?
Frequently asked questions for your trip St. Louis - Des Moines
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Des Moines was searched and found on Jul 20, 2025 with a price of $106To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Des Moines, as early as possible.
You can expect to pay from $106 to $155 for a bus ticket from St. Louis to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $106 which is on 2025-07-23.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Des Moines but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Des Moines, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Des Moines that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from St. Louis to Des Moines, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Top traveled bus routes
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Popular Buses Connecting St. Louis
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Popular Buses Connecting Des Moines
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Buses Going to Des Moines
- Bus from Washington to Des Moines
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