Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Sioux Falls | CheapestFastest | ||||
| Bus | Des Moines | Sioux Falls | No tags |
Last refresh of the prices: Yesterday at 9:37 PM CST.
Get from Des Moines to Sioux Falls
The journey takes about 14 hours 20 minutes and with fares starting at just $125, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Sioux Falls?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Sioux Falls
- A
Jefferson Lines Station I-29 & Maple St
4101 W Maple St, Sioux Falls, SD 57107, USA
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Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Frequently asked questions about traveling from Des Moines to Sioux Falls by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Sioux Falls?
The cheapest bus tickets from Des Moines to Sioux Falls start from $125. The average price for this route is around $173. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Sioux Falls?
The average bus trip duration from Des Moines to Sioux Falls is 14h 20m, covering a distance of 211 miles (339 km). The quickest bus can get you there in 6h and is operated by Jefferson Lines.
Which bus companies service the Des Moines to Sioux Falls route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Des Moines to Sioux Falls?
The earliest bus departs from Des Moines to Sioux Falls at 12:01am. And the latest bus departs at 6:50pm.
What are the CO₂ emissions for the bus trip from Des Moines to Sioux Falls?
A bus trip from Des Moines to Sioux Falls generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Sioux Falls was searched and found on Jan 10, 2026 with a price of $121To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Sioux Falls, as early as possible.
You can expect to pay from $121 to $168 for a bus ticket from Des Moines to Sioux Falls based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2026-01-10.
Top traveled bus routes
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Popular bus departures from Des Moines
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