Bus Tickets from San Ysidro, CA to Chicago

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Previously seen trips

One passenger / one way

  • Departure time: August 9 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: San Ysidro
    Departure location: San Ysidro Bus terminal
    Arrival time: August 12 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Bus San Ysidro, CA to Chicago: Trip Overview

Average ticket price$251
Average bus trip duration2d 7h
Number of daily buses4
Earliest bus departure6:55am
Distance1725 miles (2782 km)
Latest bus departure7:00pm

San Ysidro to Chicago Bus

Busbud helps you find a bus from San Ysidro to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Ysidro to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from San Ysidro to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Ysidro, CA - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/28
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08/29
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Today
$199
08/31
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09/01
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09/02
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09/03
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09/04
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busbud logoThe cheapest trip from San Ysidro, CA to Chicago was searched and found on Aug 30, 2025 with a price of $199

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Chicago, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Ysidro and Chicago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Ysidro to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Ysidro to Chicago will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from San Ysidro to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Ysidro, CA by bus?

Bus from Chicago to San Ysidro, CA

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