Bus Tickets from Chicago to San Ysidro, CA

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Previously seen trips

One passenger / one way

  • Departure time: September 13 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: September 15 at
    Destination city: San Ysidro
    Destination location: San Ysidro Greyhound Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 13 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 16 at
    Destination city: San Ysidro
    Destination location: San Ysidro Greyhound Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 13 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: September 16 at
    Destination city: San Ysidro
    Destination location: San Ysidro Greyhound Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 13 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 16 at
    Destination city: San Ysidro
    Destination location: San Ysidro Greyhound Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 13 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 16 at
    Destination city: San Ysidro
    Destination location: San Ysidro Greyhound Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:

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Bus Chicago to San Ysidro, CA: Trip Overview

Average ticket price$336
Average bus trip duration2d 8h
Number of daily buses6
Earliest bus departure9:45am
Distance1725 miles (2782 km)
Latest bus departure11:50pm

Chicago to San Ysidro Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Chicago to San Ysidro.

We make sure you can find a bus service from Chicago to San Ysidro from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Ysidro from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Chicago - San Ysidro, CA

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/28
$314
08/29
No data
Today
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08/31
No data
09/01
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09/02
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09/03
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09/04
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busbud logoThe cheapest trip from Chicago to San Ysidro, CA was searched and found on Aug 28, 2025 with a price of $314

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Ysidro, CA, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Chicago to San Ysidro but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to San Ysidro, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to San Ysidro.

Make a music playlist for your bus ride from Chicago to San Ysidro, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Chicago by bus?

Bus from San Ysidro, CA to Chicago

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