Bus Tickets from Port Saint Lucie to Charleston, SC, US

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Previously seen trips

One passenger / one way

  • Departure time: August 20 at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: August 21 at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 20 at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: August 21 at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: August 23 at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: August 23 at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 23 at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: August 24 at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: August 23 at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: August 24 at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:

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Bus Port Saint Lucie to Charleston, SC, US: Trip Overview

Average ticket price$128
Average bus trip duration22h 5m
Number of daily buses1
Earliest bus departure1:40am
Distance388 miles (625 km)
Latest bus departure3:45pm

Port Saint Lucie to Charleston Bus

With Busbud, comparing and booking tickets for a bus from Port Saint Lucie to Charleston is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Port Saint Lucie to Charleston will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Port Saint Lucie to Charleston, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Port Saint Lucie - Charleston, SC, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/27
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08/28
$95
Today
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08/30
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08/31
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09/01
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09/03
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busbud logoThe cheapest trip from Port Saint Lucie to Charleston, SC, US was searched and found on Aug 28, 2025 with a price of $95

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Charleston, SC, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Port Saint Lucie to Charleston.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Port Saint Lucie to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Port Saint Lucie to Charleston that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Port Saint Lucie to Charleston, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Port Saint Lucie by bus?

Bus from Charleston, SC, US to Port Saint Lucie

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