Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Mesa Bus Stop | 409 Townsend St, SF | No tags | ||||
Greyhound + FlixBus | Bus | Mesa Bus Stop | Hyde/Beach (Fisherman's Wharf) | No tags | ||||
 | Bus | Mesa Bus Stop | San Francisco Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Mesa Bus Stop | 409 Townsend St, SF | No tags | ||||
| Bus | Mesa Bus Stop | San Francisco Bus Station | No tags |
Get from Mesa to San Francisco
The journey takes about 22 hours 10 minutes and with fares starting at just $151, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Francisco?
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Mesa to San Francisco, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to San Francisco?
The cheapest bus tickets from Mesa to San Francisco start from $151. The average price for this route is around $231. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to San Francisco?
The average bus trip duration from Mesa to San Francisco is 22h 10m, covering a distance of 665 miles (1072 km). The quickest bus can get you there in 17h 30m and is operated by Greyhound.
Which bus companies service the Mesa to San Francisco route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Mesa to San Francisco?
The earliest bus departs from Mesa to San Francisco at 2:45pm. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Mesa to San Francisco?
A bus trip from Mesa to San Francisco generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Francisco, US was searched and found on Jan 8, 2026 with a price of $228To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Francisco, US, as early as possible.
