Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Cherry Hill Mall | Cheapest | ||||
 | Bus | Knoxville Bus Station | 199 Spring Garden St. | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Philadelphia, 199 Spring Garden St | No tags | ||||
| Bus | Knoxville Bus Station | Schuylkill & Walnut | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Frazer - 56-40 Matthews Rd | No tags |
Last refresh of the prices: Today at 3:35 PM EST.
Get from Knoxville to Philadelphia
The journey takes about 20 hours 55 minutes and with fares starting at just $88, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Philadelphia?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Knoxville, TN to Philadelphia, PA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Philadelphia?
The cheapest bus tickets from Knoxville to Philadelphia start from $88. The average price for this route is around $133. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Philadelphia?
The average bus trip duration from Knoxville to Philadelphia is 20h 55m, covering a distance of 533 miles (860 km). The quickest bus can get you there in 16h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to Philadelphia route?
Several major train operators operate on this route with 5 trains available per day.
What is the earliest and latest departure time for the bus from Knoxville to Philadelphia?
The earliest bus departs from Knoxville to Philadelphia at 10:50pm. And the latest bus departs at 10:50pm.
What are the CO₂ emissions for the bus trip from Knoxville to Philadelphia?
A bus trip from Knoxville to Philadelphia generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Philadelphia, PA was searched and found on Jan 18, 2026 with a price of $93To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Philadelphia, PA, as early as possible.
You can expect to pay from $93 to $135 for a bus ticket from Knoxville, TN to Philadelphia, PA based on the last 2 days. You can expect to find the cheapest price for the trip at $93 which is on 2026-01-18.
