Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Cherry Hill Mall | Cheapest | ||||
 | Bus | Knoxville Bus Station | 199 Spring Garden St. | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Philadelphia, 199 Spring Garden St | No tags | ||||
| Bus | Knoxville Bus Station | Schuylkill & Walnut | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Frazer - 56-40 Matthews Rd | No tags |
Last refresh of the prices: Today at 3:35 PM EST.
Get from Knoxville to Philadelphia
The journey takes about 20 hours 55 minutes, and with fares starting at just $125, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Philadelphia?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Compare bus companies
Based on 87501 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $125
Frequently asked questions about travelling from Knoxville, TN to Philadelphia, PA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Philadelphia?
The cheapest bus tickets from Knoxville to Philadelphia start from $125. The average price for this route is around $189. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Philadelphia?
The average bus travel time from Knoxville to Philadelphia is 20h 55m, covering a distance of 860 km. The quickest bus can get you there in 16h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to Philadelphia route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Philadelphia?
The earliest bus departs from Knoxville to Philadelphia at 10:50pm. And the latest bus departs at 10:50pm.
What are the CO₂ emissions for the bus trip from Knoxville to Philadelphia?
A bus trip from Knoxville to Philadelphia generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Philadelphia, PA was searched and found on Jan 18, 2026 with a price of $133To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Philadelphia, PA, as early as possible.
You can expect to pay from $133 to $193 for a bus ticket from Knoxville, TN to Philadelphia, PA based on the last 2 days. You can expect to find the cheapest price for the trip at $133 which is on 2026-01-18.
