Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Cherry Hill Mall | Cheapest | ||||
 | Bus | Knoxville Bus Station | 199 Spring Garden St. | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Philadelphia, 199 Spring Garden St | No tags | ||||
| Bus | Knoxville Bus Station | Schuylkill & Walnut | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Frazer - 56-40 Matthews Rd | No tags |
Last refresh of the prices: Today at 3:35 PM EST.
Get from Knoxville to Philadelphia
The journey takes about 20 hours 55 minutes, and with fares starting at just R 1 459, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Philadelphia?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Philadelphia
- A
Philadelphia Airport
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Compare bus companies
Based on 87501 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 1 459
Frequently asked questions about travelling from Knoxville, TN to Philadelphia, PA by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Knoxville to Philadelphia?
The cheapest bus tickets from Knoxville to Philadelphia start at R 1 459. The average price for this route is around R 2 212. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Knoxville to Philadelphia?
The average bus journey time from Knoxville to Philadelphia is 20h 55m, covering a distance of 860 km. The fastest bus gets you there in 16h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to Philadelphia route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Knoxville to Philadelphia?
The earliest bus departs from Knoxville to Philadelphia at 22:50. And the latest bus departs at 22:50.
What are the CO₂ emissions for the bus trip from Knoxville to Philadelphia?
A bus trip from Knoxville to Philadelphia produces an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Philadelphia, PA was searched and found on 18 Jan 2026 with a price of R 1 557To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Philadelphia, PA as early as possible.
You can expect to pay from R 1 557 to R 2 259 for a bus ticket from Knoxville, TN to Philadelphia, PA based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 557, which is on 2026-01-18.
