How far is Knoxville from Florence?

The distance separating Knoxville and Florence is 271 miles (436 km).

What are the departure and arrival stations when taking the bus from Knoxville to Florence?

Most of the buses traveling from Knoxville to Florence leave from 100 Kirkwood St and arrive at Florence Bus Station. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Villa Gamberaia, Tuscan Wine Tour, Galleria dell’Accademia, Cappella Brancacci and Santa Maria del Carmine and Cooking Classes in Florence.

Bus Knoxville to Florence from $128 | Compare & Save up to 20%

Bus Knoxville, TN to Florence, SC, US: Trip Overview

Average ticket price$128

Average bus trip duration1d 4h

Number of daily buses1

Earliest bus departure7:25pm

Distance264 miles (425 km)

Knoxville to Florence Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Knoxville, we help you find what you're looking for based on how much of a budget you have.

Where are the popular stops in Knoxville and Florence?

Stops in Knoxville

A - 100 Kirkwood St

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions for your trip Knoxville, TN - Florence, SC, US

How far is Knoxville from Florence?
What are the departure and arrival stations when taking the bus from Knoxville to Florence?
What are the best sights and things to do in Florence?

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Knoxville to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Knoxville to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Florence.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Knoxville, TN by bus?

Bus from Knoxville, TN to Florence, SC, US

Top traveled bus routes

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Bus Tickets from Knoxville, TN to Florence, SC, US