Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Milan (Assago M2) | Terminal Interbus | Cheapest | ||||
| Bus | Lampugnano bus station | Terminal Interbus | Fastest | ||||
| Bus | Lampugnano bus station | Terminal Interbus | No tags | ||||
| Bus | Milan (San Donato M3) | Terminal Interbus | No tags | ||||
| Bus | Milan (Malpensa Aeroporto Terminal 1) | Terminal Interbus | No tags |
Last refresh of the prices: Today at 12:59 CET.
Compare 3 ways to travel from Milano to Syracuse
Among the sustainable travel choices, the Carpool stands out as a good way to reach Syracuse. The journey takes about 15 hours 30 minutes and with fares starting at just £71, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milano and Syracuse?
Stops in Milano
- AVia Giulio Natta, 228, 20151 Milano, Italy
- CPiazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy
- EVia Giuseppe Impastato, 27, 20138 Milano, Italy
- F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 11965 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £32
Frequently asked questions about travelling by bus from Milano to Syracuse
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Milano to Syracuse?
The cheapest coach tickets from Milano to Syracuse start from £32. The average price for this route is around £101. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Milano to Syracuse?
The average bus journey time from Milano to Syracuse is 1d 3h, covering a distance of 662 miles. The fastest bus can take you there in 20h 30m and is operated by FlixBus.
Which bus companies service the Milano to Syracuse route?
Several major bus companies operate on this route with 6 buses available per day.
What is the earliest and latest departure time for the bus from Milano to Syracuse?
The earliest bus departs from Milano to Syracuse at 12:20. And the latest bus departs at 21:20.
What are the CO₂ emissions for the bus trip from Milano to Syracuse?
A bus journey from Milano to Syracuse produces an estimated 27 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milano to Syracuse was searched and found on 9 Jan 2026 with a price of £46To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milano to Syracuse as early as possible.
You can expect to pay from £46 to £130 for a bus ticket from Milano to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at £46, which is on 2026-01-09.
