Find coaches from Lyon to Brussels

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Today28 Jul
from US$43
Tomorrow29 Jul
from US$37
Wed30 Jul
from US$35
Thu31 Jul
from US$28
Fri1 Aug
from US$37
Sat2 Aug
from US$35
Sun3 Aug
from US$35
Mon4 Aug
from US$28

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 29 July at
    Departure city: Lyon
    Departure location: Lyon - Perrache Bus Station
    Arrival time: 29 July at
    Destination city: Brussels
    Destination location: Brussels-South (Gare du Midi)
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 29 July at
    Departure city: Lyon
    Departure location: Lyon - Perrache Bus Station
    Arrival time: 29 July at
    Destination city: Brussels
    Destination location: Brussels-South (Gare du Midi)
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • Departure time: 29 July at
    Departure city: Lyon
    Departure location: Lyon - Perrache Bus Station
    Arrival time: 29 July at
    Destination city: Brussels
    Destination location: Brussels-South (Gare du Midi)
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • Departure time: 29 July at
    Departure city: Lyon
    Departure location: Aéroport LYS
    Arrival time: 30 July at
    Destination city: Brussels
    Destination location: Brussels-North (Gare du Nord)
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:
  • Departure time: 29 July at
    Departure city: Lyon
    Departure location: Lyon - Perrache Bus Station
    Arrival time: 29 July at
    Destination city: Brussels
    Destination location: Brussels-South (Gare du Midi)
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:

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Compare 3 ways to travel from Lyon to Brussels

Bus
Average priceUS$26 - US$202Average duration11h 45m
14kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$78 - US$227Average duration4h 13m
14kg CO₂e5 out of 5 stars
Fastest
Carpool
Average priceUS$37 - US$136Average duration7h 40m
24kg CO₂e4 out of 5 stars
busbud logoBusbud recommends taking the train from Lyon to Brussels

Among the sustainable travel choices, the train stands out as a good way to reach Brussels. The journey takes about 4 hours 13 minutes and with fares starting at just US$78, it presents an excellent value for a comfortable ride.

12train per day
4h 13mAverage duration
US$78Cheapest ticket
14kgCO₂ emissions

Bus Lyon to Brussels: Trip Overview

Average ticket priceUS$59
Average bus trip duration11h 45m
Number of daily buses24
Earliest bus departure00:15
Distance355 miles
Latest bus departure23:59

Lyon to Brussels Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Lyon to Brussels.

We make sure you can find a bus service from Lyon to Brussels from the most reliable bus companies operating this trip.

Discover how much the bus trip from Lyon to Brussels will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Lyon - Brussels

  1. What's the distance between Lyon and Brussels by coach?

    The distance between Lyon and Brussels by coach is approximately 353 miles (569 km).

  2. How can I travel from Lyon to Brussels avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
26/07
US$52
27/07
US$99
Today
US$40
29/07
US$35
30/07
US$32
31/07
US$26
01/08
US$35
02/08
US$32
busbud logoThe cheapest trip from Lyon to Brussels was searched and found on 31 Jul 2025 with a price of US$26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels as early as possible.

You can expect to pay from US$26 to US$133 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at US$26, which is on 2025-07-31.

Usually Flixbus (FR) will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Lyon to Brussels but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Lyon to Brussels, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Lyon to Brussels will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Lyon to Brussels.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Lyon to Brussels?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Lyon by bus?

Bus from Lyon to Brussels

You can also go to Brussels by train

Train from Lyon to Brussels

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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Popular bus departures from Lyon

Popular bus departures to Lyon

Continue your journey from Brussels