Find coaches from Florence, SC, US to Jacksonville, FL

Find affordable coach tickets from Florence, SC, US to Jacksonville, FL with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.
Today20 Jun
Tomorrow21 Jun
from US$66
Sun22 Jun
from US$69
Mon23 Jun
from US$62
Tue24 Jun
from US$62
Wed25 Jun
Thu26 Jun
Fri27 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 21 June at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: 21 June at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 21 June at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: 21 June at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 21 June at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: 21 June at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to travel from Florence to Jacksonville

Bus
Average priceUS$62 - US$75Average duration5h 45m
12kg CO₂e5 out of 5 stars
FastestMost eco-friendly
Train
Average priceUS$48 - US$177Average duration6h 6m
42kg CO₂e1 out of 5 stars
Cheapest
busbud logoBusbud recommends taking the bus from Florence to Jacksonville

Among the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 5 hours 45 minutes and with fares starting at just US$62, it presents an excellent value for a comfortable ride.

2bus per day
5h 45mAverage duration
US$62Cheapest ticket
12kgCO₂ emissions

Bus Florence to Jacksonville: Trip Overview

Average ticket priceUS$66
Average bus trip duration5h 45m
Number of daily buses1.5555555555555554
Earliest bus departure05:30
Distance289 miles
Latest bus departure12:55

Florence to Jacksonville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Jacksonville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Florence to Jacksonville.

Whether it is cheap bus tickets or more luxurious buses going to Jacksonville from Florence, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Florence, SC, US - Jacksonville, FL

  1. How far is Jacksonville from Florence by coach?

    The distance between Florence and Jacksonville by coach is approximately 293 miles (472 km).

  2. Is there a way to reach Jacksonville from Florence without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
18/06
US$58
19/06
US$61
Today
US$58
21/06
US$58
22/06
US$61
23/06
US$54
24/06
US$54
25/06
US$58
busbud logoThe cheapest trip from Florence to Jacksonville was searched and found on 23 Jun 2025 with a price of US$54

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence to Jacksonville as early as possible.

You can expect to pay from US$54 to US$67 for a bus ticket from Florence to Jacksonville based on the last 2 days. You can expect to find the cheapest price for the trip at US$54, which is on 2025-06-23.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Jacksonville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Florence to Jacksonville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Florence to Jacksonville.

Make a music playlist for your bus ride from Florence to Jacksonville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Florence to Jacksonville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence by bus?

Bus from Florence to Jacksonville

You can also go to Jacksonville by train

Train from Florence to Jacksonville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence

Popular Buses Connecting Jacksonville

Buses Leaving from Jacksonville

Buses Going to Jacksonville