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One passenger / one way
- This trip is recommended because it is the: Cheapest
- This trip is recommended because it is the: FastestDeparture time: 21 June atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: 21 June atDestination city: St LouisDestination location: Gateway StationOperated by: FlixBus
Vehicle: BusDuration: - Departure time: 21 June atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: 21 June atDestination city: St LouisDestination location: Gateway StationOperated by: FlixBusVehicle: BusDuration:
- Departure time: 21 June atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: 21 June atDestination city: St LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: 21 June atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: 22 June atDestination city: St LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Compare 2 ways to travel from Detroit to St Louis
Busbud recommends taking the train from Detroit to St LouisAmong the sustainable travel choices, the train stands out as a good way to reach St Louis. The journey takes about 13 hours 41 minutes and with fares starting at just US$80, it presents an excellent value for a comfortable ride.
Bus Detroit to St Louis: Trip Overview
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Detroit to St Louis Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Detroit to St Louis.
We make sure you can find a bus service from Detroit to St Louis from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to St Louis from Detroit, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Detroit and St Louis?
Frequently asked questions on the trip Detroit, MI - St Louis
What's the distance between Detroit and St Louis by coach?
The distance between Detroit and St Louis by coach is approximately 454 miles (733 km).
What is the best way to go from Detroit to St Louis without flying?
You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit to St Louis was searched and found on 18 Jun 2025 with a price of US$86To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit to St Louis as early as possible.
You can expect to pay from US$86 to US$234 for a bus ticket from Detroit to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$88, which is on 2025-06-23.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Detroit to St Louis but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Detroit to St Louis, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Detroit to St Louis.
Tune out to the fine sounds of your best music playlist on your bus trip from Detroit to St Louis while indulging in miles on end of beautiful scenic views.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
What's the cheapest way to go from Detroit to St Louis?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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