Bus Tickets from Santa Cruz, CL to Santiago, CL

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TodaySep 2
from US$7
TomorrowSep 3
from US$7
ThuSep 4
from US$7
FriSep 5
from US$7
SatSep 6
from US$8
SunSep 7
from US$7
MonSep 8
from US$7
TueSep 9

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: September 3 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: September 3 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: September 3 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: Buses TranSantinBuses TranSantin
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: September 3 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: September 3 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: Buses TranSantinBuses TranSantin
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Santa Cruz
    Departure location: Terminal Santa Cruz
    Arrival time: September 3 at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

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Bus Santa Cruz, CL to Santiago, CL: Trip Overview

Average Ticket PriceUS$8
Average Bus Trip Duration3h
Number of daily buses25
Earliest bus departure5:00am
Distance146 km
Latest bus departure8:10pm

Santa Cruz to Santiago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Cruz to Santiago.

We make sure you can find a bus service from Santa Cruz to Santiago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santiago from Santa Cruz, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Santa Cruz, CL - Santiago, CL

  1. What is the travel distance from Santa Cruz to Santiago?

    The distance between Santa Cruz and Santiago is around 153 km (95 miles).

  2. What are the departure and arrival locations for buses traveling from Santa Cruz to Santiago?

    Buses traveling this route start their trip at Terminal Santa Cruz, in Santa Cruz, and end it at Terminal Sur, in Santiago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$7
09-01
US$7
Today
US$7
09-03
US$7
09-04
US$7
09-05
US$7
09-06
US$7
09-06
US$7
busbud logoThe cheapest trip from Santa Cruz, CL to Santiago, CL was searched and found on Sep 1, 2025 with a price of US$7

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz, CL to Santiago, CL, as early as possible.

You can expect to pay from US$7 to US$10 for a bus ticket from Santa Cruz, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$7 which is on 2025-09-07.

Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Cruz to Santiago but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Cruz to Santiago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Cruz to Santiago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santa Cruz to Santiago.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Santa Cruz, CL by bus?

Bus from Santiago, CL to Santa Cruz, CL

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