Bus Tickets from Panama City, US to Jacksonville, FL

Find affordable bus tickets from Panama City, US to Jacksonville, FL with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJun 28
from US$65
TomorrowJun 29
from US$58
MonJun 30
from US$53
TueJul 1
from US$48
WedJul 2
from US$53
ThuJul 3
from US$63
FriJul 4
SatJul 5

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 29 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: June 29 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 11:55 AM CDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Panama City to Jacksonville: Trip Overview

Average Ticket PriceUS$49
Average Bus Trip Duration6h 45m
Number of daily buses1
Earliest bus departure12:50pm
Distance394 km

Panama City to Jacksonville Bus

With Busbud, comparing and booking tickets for a bus from Panama City to Jacksonville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Panama City to Jacksonville will be provided by the most trusted bus companies.

Discover how much the bus trip from Panama City to Jacksonville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Panama City, US - Jacksonville, FL

  1. What is the distance between Panama City and Jacksonville?

    The distance covered from Panama City to Jacksonville is 387 km (240 miles).

  2. What are the departure and arrival locations for buses traveling from Panama City to Jacksonville?

    Buses traveling this route start their trip at Panama City Greyhound Bus Station, in Panama City, and end it at Jacksonville Amtrak Station, in Jacksonville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-26
No data
06-27
US$43
Today
US$57
06-29
US$50
06-30
US$45
07-01
US$40
07-02
US$45
07-03
US$55
busbud logoThe cheapest trip from Panama City to Jacksonville was searched and found on Jul 1, 2025 with a price of US$40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City to Jacksonville, as early as possible.

You can expect to pay from US$40 to US$57 for a bus ticket from Panama City to Jacksonville based on the last 2 days. You can expect to find the cheapest price for the trip at US$40 which is on 2025-07-01.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Panama City to Jacksonville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Panama City to Jacksonville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Jacksonville will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Jacksonville.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Panama City by bus?

Bus from Panama City to Jacksonville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Panama City

Buses Leaving from Panama City

Buses Going to Panama City

Popular Buses Connecting Jacksonville

Buses Leaving from Jacksonville

Buses Going to Jacksonville