Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Durham Station | Greyhound Amtrak Station | CheapestFastest | ||||
| Train | Durham Station | Greyhound Amtrak Station | No tags |
Last refresh of the prices: Last Monday at 12:07 AM EST.
Compare 2 ways to go from Durham to Indianapolis
Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 23 hours 20 minutes and with fares starting at just $123, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5671 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $146
Frequently asked questions about traveling from Durham, NC, US to Indianapolis by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Durham to Indianapolis?
The cheapest train tickets from Durham to Indianapolis start from $146. The average price for this train route is around $274. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Durham to Indianapolis?
The average train ride duration from Durham to Indianapolis is 1d 11h, covering a distance of 473 miles (762 km). The quickest train can get you there in 1d 10h and is operated by Amtrak.
Which train operators service the Durham to Indianapolis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Durham to Indianapolis?
The earliest train departs from Durham to Indianapolis at 6:04pm. And the latest train departs at 7:06pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Indianapolis was searched and found on Dec 23, 2025 with a price of $281To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Indianapolis, as early as possible.
You can expect to pay from $281 to $1,038 for a train ticket from Durham, NC, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $281 which is on 2025-12-25.
