Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Detroit Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Detroit Bus Station | Fastest |
Last refresh of the prices: Last Thursday at 7:30 PM CST.
Get from Tupelo to Detroit
The journey takes about 22 hours and with fares starting at just $186, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to Detroit, MI by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Detroit?
The cheapest bus tickets from Tupelo to Detroit start from $186. The average price for this route is around $204. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Detroit?
The average bus trip duration from Tupelo to Detroit is 22h, covering a distance of 636 miles (1025 km). The quickest bus can get you there in 22h and is operated by Greyhound.
Which bus companies service the Tupelo to Detroit route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Detroit?
The earliest bus departs from Tupelo to Detroit at 10:55am. And the latest bus departs at 9:35pm.
What are the CO₂ emissions for the bus trip from Tupelo to Detroit?
A bus trip from Tupelo to Detroit generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Detroit, MI was searched and found on Jan 14, 2026 with a price of $129To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Detroit, MI, as early as possible.
You can expect to pay from $129 to $178 for a bus ticket from Tupelo to Detroit, MI based on the last 2 days. You can expect to find the cheapest price for the trip at $129 which is on 2026-01-14.
