Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | Downtown Greyhound Station | CheapestFastest | ||||
 | Bus | Orangeburg | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | 537-517 W. Jackson Blvd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | 537-517 W. Jackson Blvd | No tags | ||||
| Bus | Orangeburg | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Last Monday at 7:21 AM EST.
Get from Orangeburg to Chicago
The journey takes about 1 day, 17 hours 15 minutes and with fares starting at just $125, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orangeburg and Chicago?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Orangeburg to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Orangeburg to Chicago?
The cheapest bus tickets from Orangeburg to Chicago start from $125. The average price for this route is around $228. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Orangeburg to Chicago?
The average bus trip duration from Orangeburg to Chicago is 1d 17h, covering a distance of 686 miles (1107 km). The quickest bus can get you there in 1d 3h and is operated by FlixBus.
Which bus companies service the Orangeburg to Chicago route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Orangeburg to Chicago?
The earliest bus departs from Orangeburg to Chicago at 1:45pm. And the latest bus departs at 9:55pm.
What are the CO₂ emissions for the bus trip from Orangeburg to Chicago?
A bus trip from Orangeburg to Chicago generates an estimated 28 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orangeburg to Chicago was searched and found on Jan 22, 2026 with a price of $117To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orangeburg to Chicago, as early as possible.
You can expect to pay from $117 to $218 for a bus ticket from Orangeburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $117 which is on 2026-01-22.
Top traveled bus routes
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Popular bus departures from Orangeburg
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