Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orangeburg | Downtown Greyhound Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | Downtown Greyhound Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | 537-517 W. Jackson Blvd | No tags | ||||
| Bus | Orangeburg | Chicago 95Th & Dan Ryan | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orangeburg | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Last Tuesday at 2:14 PM EST.
Get from Orangeburg to Chicago
The journey takes about 1 day, 17 hours 15 minutes, and with fares starting at just $178, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orangeburg and Chicago?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 12083 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. FlixBus ticket prices on this trip start at $180
Frequently asked questions about travelling from Orangeburg to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Orangeburg to Chicago?
The cheapest bus tickets from Orangeburg to Chicago start from $178. The average price for this route is around $325. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Orangeburg to Chicago?
The average bus travel time from Orangeburg to Chicago is 1d 17h, covering a distance of 1107 km. The quickest bus can get you there in 1d 3h and is operated by FlixBus.
Which bus companies service the Orangeburg to Chicago route?
Several major bus companies operate on this route with 4 buses available per day.
What are the earliest and latest departure times for the bus from Orangeburg to Chicago?
The earliest bus departs from Orangeburg to Chicago at 1:45pm. And the latest bus departs at 9:55pm.
What are the CO₂ emissions for the bus trip from Orangeburg to Chicago?
A bus trip from Orangeburg to Chicago generates an estimated 28 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orangeburg to Chicago was searched and found on Jan 22, 2026 with a price of $167To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orangeburg to Chicago, as early as possible.
You can expect to pay from $167 to $312 for a bus ticket from Orangeburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $167 which is on 2026-01-22.
