Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines (Subway) | Knoxville Bus Station | No tags | ||||
| Bus | Des Moines (Subway) | Knoxville Bus Station | No tags | ||||
| Bus | Des Moines (Subway) | Knoxville Bus Station | No tags | ||||
| Bus | Des Moines | Knoxville Bus Station | No tags |
Get from Des Moines to Knoxville
The journey takes about 1 day, 8 hours 10 minutes and with fares starting at just $139, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Knoxville?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Des Moines to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Knoxville?
The cheapest bus tickets from Des Moines to Knoxville start from $139. The average price for this route is around $148. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Knoxville?
The average bus trip duration from Des Moines to Knoxville is 1d 8h, covering a distance of 650 miles (1048 km). The quickest bus can get you there in 1d 8h and is operated by Greyhound.
Which bus companies service the Des Moines to Knoxville route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Des Moines to Knoxville?
The earliest bus departs from Des Moines to Knoxville at 9:45am. And the latest bus departs at 9:45am.
What are the CO₂ emissions for the bus trip from Des Moines to Knoxville?
A bus trip from Des Moines to Knoxville generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
