Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Chicago 95Th & Dan Ryan | Florence, SC | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | Florence, SC | No tags | ||||
 | Bus | 537-517 W. Jackson Blvd | Bus station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 537-517 W. Jackson Blvd | Florence, SC | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Bus station | No tags |
Last refresh of the prices: Yesterday at 10:09 AM CST.
Compare 2 ways to go from Chicago to Florence
Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 1 day, 4 hours 5 minutes and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Florence?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about traveling from Chicago to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Florence?
The cheapest bus tickets from Chicago to Florence start from $111. The average price for this route is around $192. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Florence?
The average bus trip duration from Chicago to Florence is 1d 4h, covering a distance of 681 miles (1097 km). The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Chicago to Florence route?
What is the earliest and latest departure time for the bus from Chicago to Florence?
The earliest bus departs from Chicago to Florence at 8:25am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to Florence?
A bus trip from Chicago to Florence generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from Chicago to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Chicago to Florence?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Florence, SC, US was searched and found on Dec 25, 2025 with a price of $212To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Florence, SC, US, as early as possible.
What's the cheapest way to go from Chicago to Florence, SC, US?
The bus is the cheapest travel choice for this destination
