Bus Tickets from Charleston, SC, US to St. Louis

Previously seen trips

Next departures for Charleston to St. Louis on September 18
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
4565 Gaynor Ave, North Charleston
Gateway StationNo tags
FlixBus + Greyhound
4565 Gaynor Ave, North Charleston
Gateway StationNo tags
Greyhound
4565 Gaynor Ave, North Charleston
Gateway StationNo tags
FlixBus + Greyhound
4565 Gaynor Ave, North Charleston
Gateway StationNo tags
Greyhound + FlixBus
4565 Gaynor Ave, North Charleston
Gateway StationNo tags

Accepted payments

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Compare 2 ways to go from Charleston to St. Louis.

Bus
Average Price$91 - $190Average Duration1d 1h
28kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$526 - $526Average Duration1d 22h
102kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Charleston to St. Louis

Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 1 hour 30 minutes and with fares starting at just $91, it presents an excellent value for a comfortable ride.

1bus per day
1d 1hAverage Duration
$91Cheapest ticket
28kgCO₂ emissions

Bus Charleston, SC, US to St. Louis: Trip Overview

Average ticket price$104
Average bus trip duration1d 1h
Number of daily buses1
Earliest bus departure3:15pm
Distance695 miles (1120 km)

Charleston to St. Louis Bus

Busbud helps you find a bus from Charleston to St. Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Charleston to St. Louis.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Charleston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Charleston, SC, US - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/16
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09/17
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Today
$94
09/19
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09/20
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09/21
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busbud logoThe cheapest trip from Charleston, SC, US to St. Louis was searched and found on Sep 18, 2025 with a price of $94

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to St. Louis, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Charleston and St. Louis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Charleston to St. Louis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Charleston to St. Louis.

Tune out to the fine sounds of your best music playlist on your bus trip from Charleston to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Charleston, SC, US to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Charleston, SC, US by bus?

Bus from St. Louis to Charleston, SC, US

Why choose Busbud?

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