Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Brussels South (Gare du Midi) | Florenc | CheapestFastest |
Last refresh of the prices: Last Saturday at 9:59 PM CET.
Compare 2 ways to travel from Brussels to Prague
Among the sustainable travel choices, the bus stands out as a good way to reach Prague. The journey takes about 19 hours 15 minutes and with fares starting at just R 762, it presents an excellent value for a comfortable ride.
Where are the popular stops in Brussels and Prague?
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- BChlumecká, 198 00 Praha 20, Czech Republic
- CKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- DTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling from Brussels to Prague by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Brussels to Prague?
The cheapest bus tickets from Brussels to Prague start at R 762. The average price for this route is around R 1 330. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Brussels to Prague?
The average bus journey time from Brussels to Prague is 19h 15m, covering a distance of 708 km. The fastest bus gets you there in 11h 55m and is operated by RegioJet.
Which bus companies service the Brussels to Prague route?
Several major bus companies operate on this route with 29 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus, Musil Tour.
What is the earliest and latest departure time for the bus from Brussels to Prague?
The earliest bus departs from Brussels to Prague at 00:45. And the latest bus departs at 23:35.
What are the CO₂ emissions for the bus trip from Brussels to Prague?
A bus trip from Brussels to Prague produces an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Brussels to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1058 reviews.
Which bus company has the best Wi-Fi from Brussels to Prague?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Brussels to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Brussels to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Prague was searched and found on 15 Dec 2025 with a price of R 977To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Prague as early as possible.
You can expect to pay from R 977 to R 4 179 for a bus ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 561, which is on 2025-12-18.
What's the cheapest way to go from Brussels to Prague?
The bus is the cheapest travel choice for this destination
