Next bus departures Today, 19 Mar Tomorrow, 20 Mar Sat, 21 Mar Mon, 23 Mar Tue, 24 Mar More dates
Next departures from Brussels to Prague on 19 March Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 18:30
Brussels South (Gare du Midi) 11h 55m 06:25
Florenc Cheapest Fastest £47 Bus 16:30
Brussels North Train Station 18h 10m 10:40
Prague (Central Bus Station Florenc) No tags £90 Bus 21:30
Brussels North Train Station 15h 10m 12:40
Prague (Central Bus Station Florenc) No tags £69 Bus 22:55
Brussels North Train Station 18h 35m 17:30
Prague (Main Railway Station) No tags £64 Bus 21:30
Brussels North Train Station 16h 30m 14:00
Prague (Main Station - parking) No tags £86
Next departures from Brussels to Prague on 20 March Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 20:10
Brussels-South (Gare du Midi) 13h 35m 09:45
Florenc Cheapest £44 Bus 09:00
Brussels North Train Station 12h 50m 21:50
Prague (Central Bus Station Florenc) Fastest £64 Bus 15:55
Brussels North Train Station 15h 06:55
Prague (Central Bus Station Florenc) No tags £63 Bus 17:10
Brussels North Train Station 17h 10:10
Prague (Central Bus Station Florenc) No tags £80 Bus 21:30
Brussels North Train Station 15h 10m 12:40
Prague (Central Bus Station Florenc) No tags £76
Next departures from Brussels to Prague on 21 March Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 10:30
Brussels North Train Station 13h 55m 00:25
Prague (Main Railway Station) Cheapest £46 Bus 09:30
Brussels North Train Station 12h 50m 22:20
Prague (Central Bus Station Florenc) Fastest £56 Bus 15:55
Brussels North Train Station 15h 06:55
Prague (Central Bus Station Florenc) No tags £52 Bus 18:30
Brussels North Train Station 14h 50m 09:20
Prague (Central Bus Station Florenc) No tags £60 Bus 21:30
Brussels North Train Station 15h 10m 12:40
Prague (Central Bus Station Florenc) No tags £53
Next departures from Brussels to Prague on 23 March Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 14:20
Brussels-South (Gare du Midi) 19h 25m 09:45
Florenc Cheapest Fastest £57
Next departures from Brussels to Prague on 24 March Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 09:30
Brussels North Train Station 12h 50m 22:20
Prague (Central Bus Station Florenc) Cheapest Fastest £36 Bus 15:55
Brussels North Train Station 15h 06:55
Prague (Central Bus Station Florenc) No tags £41 Bus 18:30
Brussels North Train Station 14h 50m 09:20
Prague (Central Bus Station Florenc) No tags £44 Bus 21:00
Brussels North Train Station 17h 20m 14:20
Prague (Central Bus Station Florenc) No tags £48 Bus 10:30
Brussels North Train Station 13h 55m 00:25
Prague (Main Railway Station) No tags £37
Last refresh of the prices: Today at 07:20 CET.
View all departures Where are the popular stops in Brussels and Prague? Stops in Brussels B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium Map
D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium Stops in Prague A
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic Map
Find cheapest prices for buses Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Prague was searched and found on 24 Mar 2026 with a price of £34 To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Prague as early as possible.
You can expect to pay from £34 to £118 for a bus ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at £34, which is on 2026-03-24.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
People from around the world trust Busbud
Popular bus departures from Brussels Popular bus routes to Prague Continue your journey from Prague 
The cheapest trip from Brussels to Prague was searched and found on 24 Mar 2026 with a price of £34
