Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Tampa Bus Station | Bus station | Cheapest | |||||
 | Union Station | Florence Station | Fastest | |||||
| Union Station | Florence Station | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Tampa Bus Station | Florence, SC | No tags | |||||
| University of South Florida | Bus station | No tags |
Accepted payments
Compare 2 ways to go from Tampa to Florence
Busbud recommends taking the bus from Tampa to FlorenceAmong the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 18 hours 40 minutes, and with fares starting at just US$58, it presents an excellent value for a comfortable ride.
Bus Tampa to Florence, SC, US: Trip Overview
Compare bus companies
Tampa to Florence Bus
Busbud helps you find a bus from Tampa to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Tampa to Florence.
Whether it is cheap bus tickets or more luxurious buses going to Florence from Tampa, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Tampa and Florence?
Frequently asked questions on the trip Tampa - Florence, SC, US
What is the travel distance from Tampa to Florence?
The distance between Tampa and Florence is approximately 747 km (464 miles).
What are the departure and arrival locations for buses traveling from Tampa to Florence?
Buses departing from Tampa 13th Avenue Bus Stop (McDonald's) in Tampa will take you to Florence Bus Station in Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Florence, SC, US was searched and found on Sep 27, 2025 with a price of US$48To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US, as early as possible.
You can expect to pay from US$48 to US$520 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$48 which is on 2025-09-27.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tampa and Florence!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tampa to Florence.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Florence.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Florence.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Tampa to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Buses Connecting Tampa
Buses Leaving from Tampa
- Bus from Tampa to Orlando
- Bus Tampa - Miami
- Tampa - Miami
- Bus from Tampa to Atlanta
- Bus Tampa - Sarasota
- Tampa - Jacksonville
- Bus from Tampa to Fort Myers
- Bus Tampa - Ocala
- Tampa - Gainesville
- Bus from Tampa to Naples
- Bus Tampa - Fort Lauderdale
- Tampa - St. Petersburg
- Bus from Tampa to Port Saint Lucie
- Bus Tampa - Key West
- Tampa - Spring Hill
Buses Going to Tampa
- Bus from Orlando to Tampa
- Bus Fort Myers - Tampa
- St. Petersburg - Tampa
- Bus from Boston to Tampa
- Bus Naples - Tampa
- Jackson - Tampa
- Bus from Miami to Tampa
- Bus Kissimmee - Tampa
- Ocala - Tampa
- Bus from Sarasota to Tampa
- Bus Fort Lauderdale - Tampa
- Tallahassee - Tampa
- Bus from West Palm Beach to Tampa
- Bus New York City - Tampa
- Gainesville - Tampa
Popular Buses Connecting Florence
Buses Leaving from Florence
- Bus from Florence to Kansas City
- Bus Florence - Kansas City
- Florence - Oklahoma City
- Bus from Florence to Washington
- Bus Florence - Montgomery
- Florence - Jackson
- Bus from Florence to Cincinnati
- Bus Florence - Chicago
- Florence - Miami
- Bus from Florence to Manchester
- Bus Florence - Easton
- Florence - Columbus
- Bus from Florence to Richmond
- Bus Florence - Greensboro
- Florence - Opelika
Buses Going to Florence
- Bus from Syracuse to Florence
- Bus Manchester - Florence
- Columbus - Florence
- Bus from Columbus to Florence
- Bus Los Angeles - Florence
- Toronto - Florence
- Bus from Greensboro to Florence
- Bus Portland - Florence
- Boston - Florence
- Bus from Orlando to Florence
- Bus West Palm Beach - Florence
- New York City - Florence
- Bus from New Haven to Florence
- Bus New Carrollton - Florence
- Durham - Florence
Popular routes in this country
- Bus from Boston to New York City
- Bus Washington - New York City
- New York City - Boston
- Bus from Buffalo to New York City
- Bus Philadelphia - New York City
- Niagara Falls - New York City
- Bus from Baltimore to New York City
- Bus Detroit - Chicago
- Baton Rouge - New Orleans
- Bus from Albany to New York City
- Bus Los Angeles - San Francisco
- Miami - Orlando
- Bus from Las Vegas to Los Angeles
- Bus Los Angeles - San Diego
- Atlanta - Savannah