Bus Tickets from Tampa to Florence, SC, US

TodayJul 30
TomorrowJul 31
FriAug 1
from US$99
SatAug 2
SunAug 3
MonAug 4
from US$86
TueAug 5
from US$82
WedAug 6
from US$79

Next departures to Florence

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 1 at
    Departure city: Tampa
    Departure location: Union Station
    Arrival time: August 1 at
    Destination city: Florence
    Destination location: Florence Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Tampa
    Departure location: Union Station
    Arrival time: August 1 at
    Destination city: Florence
    Destination location: Florence Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Tampa
    Departure location: Tampa Bus Station
    Arrival time: August 2 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Tampa
    Departure location: Tampa Bus Station
    Arrival time: August 3 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Tampa
    Departure location: Tampa Bus Station
    Arrival time: August 2 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 1:39 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Tampa to Florence

Bus
Average PriceUS$68 - US$166Average Duration18h 15m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$93 - US$93Average Duration18h 4m
67kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Tampa to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 18 hours 4 minutes, and with fares starting at just US$93, it presents an excellent value for a comfortable ride.

1train per day
18h 4mAverage Duration
US$93Cheapest ticket
67kgCO₂ emissions

Bus Tampa to Florence, SC, US: Trip Overview

Average Ticket PriceUS$89
Average Bus Trip Duration18h 15m
Number of daily buses4
Earliest bus departure9:30am
Distance740 km
Latest bus departure10:35pm

Tampa to Florence Bus

Busbud helps you find a bus from Tampa to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tampa to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Tampa, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Tampa - Florence, SC, US

  1. What is the travel distance from Tampa to Florence?

    The distance between Tampa and Florence is approximately 747 km (464 miles).

  2. What are the departure and arrival locations for buses traveling from Tampa to Florence?

    Buses departing from Tampa 13th Avenue Bus Stop (McDonald's) in Tampa will take you to Florence Bus Station in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-28
US$105
07-29
US$121
Today
US$92
07-31
US$64
08-01
US$94
08-02
US$67
08-03
US$70
08-04
US$78
busbud logoThe cheapest trip from Tampa to Florence, SC, US was searched and found on Jul 31, 2025 with a price of US$64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US, as early as possible.

You can expect to pay from US$64 to US$520 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$64 which is on 2025-07-31.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tampa and Florence!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tampa to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Florence.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Tampa to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Tampa by bus?

Bus from Tampa to Florence, SC, US

You can also go to Florence, SC, US by train

Train from Tampa to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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