Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus station | Downtown Greyhound Station | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | Florence, SC | 537-517 W. Jackson Blvd | Fastest | |||||
FlixBus + Greyhound Lines, Inc. | Bus station | Downtown Greyhound Station | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Bus station | 537-517 W. Jackson Blvd | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Florence, SC | Downtown Greyhound Station | No tags |
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Compare 2 ways to go from Florence to Chicago
Busbud recommends taking the bus from Florence to ChicagoAmong the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 6 hours 35 minutes, and with fares starting at just US$87, it presents an excellent value for a comfortable ride.
Bus Florence, SC, US to Chicago: Trip Overview
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Florence to Chicago Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Chicago.
We make sure you can find a bus service from Florence to Chicago from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Florence to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Florence and Chicago?
Frequently asked questions on the trip Florence, SC, US - Chicago
How far is Florence from Chicago?
The distance between Florence and Chicago is around 1102 km (684 miles).
What are the departure and arrival locations for buses traveling from Florence to Chicago?
Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Chicago was searched and found on Aug 21, 2025 with a price of US$159To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.
You can expect to pay from US$159 to US$171 for a bus ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$171 which is on 2025-08-25.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Chicago, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Florence to Chicago that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Florence to Chicago.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
What's the cheapest way to go from Florence, SC, US to Chicago?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
Why choose Busbud?
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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
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