Bus Tickets from Santiago, CL to San Luis, AR

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Previously seen trips

One passenger / one way

  • Departure time: July 15 at
    Departure city: Santiago
    Departure location: Santiago De Chile
    Arrival time: July 15 at
    Destination city: San Luis
    Destination location: Ediro San Luis
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • Departure time: July 18 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: July 18 at
    Destination city: San Luis
    Destination location: Terminal de San Luis
    Operated by: Via Bariloche + Buses Ahumada Internacional
    Via Bariloche + Buses Ahumada Internacional
    Vehicle: BusDuration:
  • Departure time: July 18 at
    Departure city: Santiago
    Departure location: Terminal Los Héroes
    Arrival time: July 18 at
    Destination city: San Luis
    Destination location: Terminal de San Luis
    Operated by: Via Bariloche + Buses Ahumada Internacional
    Via Bariloche + Buses Ahumada Internacional
    Vehicle: BusDuration:
  • Departure time: July 22 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: July 22 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: Andesmar + CATA Internacional
    Andesmar + CATA Internacional
    Vehicle: BusDuration:
  • Departure time: July 22 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: July 22 at
    Destination city: San Luis
    Destination location: Estación de Interconexión Regional de Ómnibus de San Luis
    Operated by: Andesmar + Del Sur y Media Agua
    Andesmar + Del Sur y Media Agua
    Vehicle: BusDuration:

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Bus Santiago, CL to San Luis, AR: Trip Overview

Average Ticket PriceUS$83
Average Bus Trip Duration9h
Number of daily buses2
Earliest bus departure7:30am
Distance407 km
Latest bus departure12:00pm

Santiago to San Luis Bus

With Busbud, comparing and booking tickets for a bus from Santiago to San Luis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to San Luis from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to San Luis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - San Luis, AR

  1. How far is Santiago from San Luis?

    The distance between Santiago and San Luis is approximately 394 km (245 miles).

  2. What are the departure and arrival locations for buses traveling from Santiago to San Luis?

    Buses departing from Terminal Sur in Santiago will take you to Estación de Interconexión Regional de Ómnibus de San Luis in San Luis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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09-06
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Today
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09-09
US$58
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busbud logoThe cheapest trip from Santiago, CL to San Luis, AR was searched and found on Sep 9, 2025 with a price of US$58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to San Luis, AR, as early as possible.

You can expect to pay from US$58 to US$69 for a bus ticket from Santiago, CL to San Luis, AR based on the last 2 days. You can expect to find the cheapest price for the trip at US$58 which is on 2025-09-09.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to San Luis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to San Luis, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to San Luis will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to San Luis while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Santiago, CL by bus?

Bus from San Luis, AR to Santiago, CL

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