Bus Tickets from San Luis Obispo to Santa Clara, US

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MonSep 1
from US$57
TueSep 2
WedSep 3
from US$57
ThuSep 4
from US$57
FriSep 5
from US$57
SatSep 6
from US$57
SunSep 7
MonSep 8

Next departures to Santa Clara

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 3 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: September 3 at
    Destination city: Santa Clara
    Destination location: Santa Ana Regional Transportation Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 3 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: September 3 at
    Destination city: Santa Clara
    Destination location: Santa Clara Transit Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: September 3 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: September 3 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: San Luis Obispo
    Departure location: Cal Poly Vista Grande Dining Complex
    Arrival time: September 3 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from San Luis Obispo to Santa Clara

Bus
Average PriceUS$76 - US$78Average Duration8h 15m
8kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$275 - US$275Average Duration11h 53m
28kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from San Luis Obispo to Santa Clara

Among the sustainable travel choices, the bus stands out as a good way to reach Santa Clara. The journey takes about 8 hours 15 minutes, and with fares starting at just US$76, it presents an excellent value for a comfortable ride.

2bus per day
8h 15mAverage Duration
US$76Cheapest ticket
8kgCO₂ emissions

Bus San Luis Obispo to Santa Clara, US: Trip Overview

Average Ticket PriceUS$76
Average Bus Trip Duration8h 15m
Number of daily buses2
Earliest bus departure6:50pm
Distance307 km
Latest bus departure7:25pm

San Luis Obispo to Santa Clara Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Luis Obispo to Santa Clara.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to Santa Clara.

Discover how much the bus trip from San Luis Obispo to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip San Luis Obispo - Santa Clara, US

  1. What is the distance between San Luis Obispo and Santa Clara?

    The distance between San Luis Obispo and Santa Clara is around 264 km (164 miles).

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-28
US$53
08-29
US$53
Today
US$53
08-31
US$53
09-01
US$53
09-02
US$53
09-03
US$53
09-04
US$53
busbud logoThe cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on Aug 28, 2025 with a price of US$53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US, as early as possible.

You can expect to pay from US$53 to US$107 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$53 which is on 2025-08-31.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Luis Obispo to Santa Clara but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to Santa Clara.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Luis Obispo to Santa Clara will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to Santa Clara while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from San Luis Obispo to Santa Clara, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Luis Obispo by bus?

Bus from Santa Clara, US to San Luis Obispo

You can also go to Santa Clara, US by train

Train from San Luis Obispo to Santa Clara, US

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